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Each tablet of Cardizem contains 30 mg, 60 mg, 90 mg, or 120 mg diltiazem hydrochloride. Cardizem has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. Decreases in blood pressure associated with Cardizem therapy may occasionally result in symptomatic hypotension. Single oral doses of 30 to 120 mg of Cardizem tablets result in detectable plasma levels within 30 to 60 minutes and peak plasma levels 2 to 4 hours after drug administration. Cardizem has been shown to be a potent dilator of coronary arteries both epicardial and subendocardial. Spontaneous and ergonovine-induced coronary artery spasm are inhibited by Cardizem.
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